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KMID : 0613820120220081126
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Journal of Life Science
2012 Volume.22 No. 8 p.1126 ~ p.1131
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Effect of Trans-unsaturated Fatty Acid on Serum Lipid Levels in Mice
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Yu Sun-Nyoung
Ahn Jeong-Bin
Park Eun-Young
Lee Sun-Jung
Tak Min-Gi
Kim Kwang-Youn
Kim Sang-Hun
Kim Ki-Dae
Ahn Soon-Cheol
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Abstract
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The purpose of this study was to investigate the effects of trans-unsaturated fatty acid (TFA), saturated fatty acid (SFA) and general unsaturated fatty acid (USFA) on serum lipid levels in ICR mice. Male ICR 8-week-old mice were divided into six groups; the control group (C) fed with normal diet, the TFA-1 group fed with 10% trans-unsaturated fatty acid, the TFA-2 group fed with 30% trans-unsaturated fatty acid, the TFA-3 group fed with 50% trans-unsaturated fatty acid, the SFA group fed with 50% saturated fatty acid, and USFA group fed with 50% general unsaturated fatty acid. The serum total cholesterol of TFA-3 and SFA was higher than those of other fat groups and C. The serum triglyceride (TG) of TFA-3 and SFA showed the highest levels among all of diet groups. Also the serum HDL cholesterol levels of TFA-3 showed the lowest. LDL cholesterol and atherogenic indices (AI) were remarkedly increased in TFA-3 and SFA, as compared with other fat fed groups and C. Taken together with results, the TFA-3 group showed serum lipid levels similar to the SFA and different from the USFA. These results suggest that intake of high level of trans-unsaturated fatty acid increased serum triglyceride, LDL cholesterol and atherogenic indices, which may affect risk on serum lipid level for lipid metabolism syndrome.
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KEYWORD
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Trans-unsaturated fatty acid, saturated fatty acid, general unsaturated fatty acid, serum lipid level, atherogenic indices
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